"Response of Stressors" Hans Selye Hand Signed Bio Page Todd Mueller COA

Description

Up for auction
"Response of Stressors" Hans Selye Hand Signed Bio Page.
This item is certified authentic by Todd Mueller Autographs and comes with their Certificate of Authenticity.
ES-4872E
János Hugo Bruno
"
Hans
"
Selye
CC
(
/ˈsɛljeɪ/
;
Hungarian
:
Selye János
; January 26, 1907 – October 16, 1982), was a pioneering Hungarian-Canadian
endocrinologist
. He conducted important scientific work on the hypothetical non-specific response of an organism to
stressors
. Although he did not recognize all of the many aspects of
glucocorticoids
, Selye was aware of their role in the stress response. Charlotte Gerson considers him the first to demonstrate the existence of
biological stress
. Selye was born in
Vienna
,
Austria-Hungary
on January 26, 1907 and grew up in
Komárom
, Hungary. Selye's father was a doctor of Hungarian
ethnicity
and his mother was Austrian. He became a Doctor of Medicine and Chemistry in
Prague
in 1929 and went on to do pioneering work in stress and endocrinology at
Johns Hopkins University
,
McGill University
, and the
Université de Montréal
. He was nominated for the
Nobel prize
in Physiology or Medicine for the first time in 1949. Although he received a total of 17 nominations in his career, he never won the prize.
Selye died on October 16, 1982 in
Montreal, Quebec
, Canada. He often returned to visit Hungary, giving lectures as well as interviews in Hungarian television programs. He conducted a lecture in 1973 at the Hungarian Scientific Academy in Hungarian and observers noted that he had no accent, despite spending many years abroad. His book
The Stress of Life
appeared in Hungarian as
Az Életünk és a stressz
in 1964 and became a bestseller.
Selye János University
, the only
Hungarian-language
university
in
Slovakia
, was named after him. Selye's mother was killed by gunfire during Hungary's anti-Communist revolt of 1956. Selye's interest in stress began when he was in medical school; he had observed that patients with various chronic illnesses like tuberculosis and cancer appeared to display a common set of symptoms that he attributed to what is now commonly called stress. After completing his medical degree and a doctorate degree in organic chemistry at the German University of Prague, he received a Rockefeller Foundation fellowship to study at Johns Hopkins in Baltimore and later moved to the Department of Biochemistry at McGill University in Montreal where he studied under the sponsorship of James Bertram Collip. While working with laboratory animals, Selye observed a phenomenon that he thought resembled what he had previously seen in chronic patients. Rats exposed to cold, drugs, or surgical injury exhibited a common pattern of responses; this "general adaptation syndrome" or "Selyes syndrome" was triphasic, involving an initial alarm phase followed by a stage of resistance or adaptation and, finally, a stage of exhaustion and death. Working with doctoral student Thomas McKeown (1912–88), Selye published a report that used the word “stress” to describe these responses to adverse events.
His last inspiration for
general adaptation syndrome
(GAS, a theory of
stress
) came from an endocrinological experiment in which he injected mice with extracts of various organs. He at first believed he had discovered a new hormone, but was proved wrong when every irritating substance he injected produced the same symptoms (swelling of the
adrenal cortex
, atrophy of the
thymus
, gastric and duodenal ulcers). This, paired with his observation that people with different diseases exhibit similar symptoms, led to his description of the effects of "noxious agents" as he at first called it. He later coined the term "
stress
", which has been accepted into the lexicon of most other languages.
Selye has acknowledged the influence of
Claude Bernard
(who developed the idea of
milieu intérieur
) and
Walter Cannon
's "
homeostasis
". Selye conceptualized the physiology of stress as having two components: a set of responses which he called the "
general adaptation syndrome
", and the development of a pathological state from ongoing, unrelieved stress. Selye discovered and documented that stress differs from other physical responses in that stress is stressful whether one receives good or bad news, whether the impulse is positive or negative. He called negative stress "
distress
" and positive stress "
eustress
". The system whereby the body copes with stress, the
hypothalamic-pituitary-adrenal axis
(HPA axis) system, was also first described by Selye. He also pointed to an "alarm state", a "resistance state", and an "exhaustion state", largely referring to glandular states. Later he developed the idea of two "reservoirs" of stress resistance, or alternatively stress energy. Selye wrote
The Stress of Life
(1956),
From Dream to Discovery: On Being a Scientist
(1964) and
Stress without Distress
(1974). He worked as a professor and director of the Institute of Experimental Medicine and Surgery at the
Université de Montréal
. In 1975 he created the International Institute of Stress, and in 1979, Dr. Selye and Arthur Antille started the Hans Selye Foundation. Later Selye and eight Nobel laureates founded the Canadian Institute of Stress.
In 1968 he was made a
Companion of the Order of Canada
. In 1976, he was awarded the Loyola Medal by
Concordia University
.